in Health and Fitness

What Substances Affect AMPK Activation?

The activation of AMPK is touted as one of the best means in order for us to stay fit and healthy. There have been a lot of benefits associated with its activation, which includes prevention of free radicals from proliferating, as well as allowing you to shed those unwanted pounds and body fat much faster than without trying to activate it. It is found in several parts of the body, and the benefits correspond to the AMPK which is being activated. More information about this wondrous substance could be found at If you’re wondering about what exactly allows AMPK Activation, below are the substances that allow for it.

Synthetic Drugs

There are a wide variety of drugs which you could avail of in the market nowadays, but these are not recommended for you to take when not feeling ill, or when not having any underlying diseases. Some of these include Aspirin, specifically Salicylate, which activates AMPK directly, and also allows fat burning during the fasting state. Other effective drugs for this include Metformin, as well as Thiazolidinediones, which work by activating the AMPK Cells in the liver, fat, and muscle tissues.

Natural Supplements

There are several natural supplements that work just like synthetic drugs, specifically by activating AMPK in the fat tissues, liver, and the muscle. Taking of these natural supplements allow benefits to arise among people with Type-2 diabetes and metabolic syndrome. Some of these include EGCG, Apigenin, Berberine, Curcumin, Quercetine, A-Lipoic Acid, Bitter Melon, etc. all of which are supplements naturally derived from plants.


While some supplements could be found externally, AMPK could be activated by the hormones in your own body as well! Basically, any modulator which is the cause of accumulation of calcium helps to activate AMPK in the body. Some of these include Adiponectin, Leptin, ROS-producing Agents, and Thyroid hormone T3.

Written By:

Hi there, my name is Melissa Glade. I am 28 years old and I was born (and still live) in Brisbane. My occupation is Social Media coach!

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